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We searched the ChEMBL database (v21, last update: 01/02/2016, downloaded on 11/02/16) to identify whether any of the implicated genes encoded proteins that were targets for approved drugs, or drug compounds in development. We additionally searched for genes predicted to interact (parameters: STRING score ≥0.90; maximum of 10 interactions per gene) with each of the high-priority genes32.
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