Specific pathogen free (SPF) male SD rats (160–180 g, 6–8 W) were purchased from experimental animal center of Chongqing Medical University [certificate number SCXK (Yu) 2017–0001], raised in SPF animal experiment room (constant temperature 20 ± 3 °C with 55% ± 10% humidity, 12 h light/dark cycle). All animal experiments were performed according to institutional, local, and national guidelines on animal research and ethics. Human heart samples were from the death patients with MI. Patients or patients’ family members were well informed. The animals and human heart sections used for this study were approved by the local ethic committee (Number 2017–174).
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