In total, we selected 750 women recently diagnosed with either invasive or in situ breast cancer, as confirmed by histology, at the NCC in Korea between February 2013 and October 2016. Healthy controls were selected from the KoGES, a population-based cohort constructed by the National Research Institute of Health (NIH), and the Centers for Disease Control and Prevention of Korea. Full details of the KoGES are described elsewhere38. Female control participants with a history of cancer were excluded, and 3986 women were considered for the study. Among these, 3977 controls provided information on alcohol consumption. All participants were from Korea, and written informed consent was obtained before enrolment. This study was approved by the National Cancer Center Institutional Review Board (IRB No. NCC 2015-0177). All procedures were performed in accordance with the Declaration of Helsinki.
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