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Thapsigargin (Tg) was purchased from Sigma (T9033). The Tg analogs 8-O-debutanoyl-8-O-N-L-Leucinoyl-12-aminododecanoylthapsigargin (Leu-8ADT) and 8-O-debutanoyl-8-O-N-L-β-aspartoyl-12-aminododecanoylthapsigargin (βAsp-8ADT) were synthesized as previously described [60]. The PERK inhibitor GSK2606414 [61] was a kind gift from Dr. Jeffrey M. Axten (GlaxoSmithKline). The JNK inhibitor JNK-IN-8 was from Sigma (SML1246). The chemical structures of Tg, Leu-8ADT, βAsp-8ADT, GSK2606414, and JNK-IN-8 are depicted in Additional file 1: Figure S1.

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