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Chromatin state maps data were obtained from the NIH-initiated Roadmap Epigenomics Project2, which we used to determine genomic location and infer DMR function. A chromatin map of 15 different states constructed from HeLa-S3 cervical cancer cells including five histone marks (H3K4me1, H3K4me3, H3K36me3, H3K27me3, and H3K9me3) was downloaded to as HeLa cell reference (Epigenome ID: E117) (Roadmap Epigenomics Project3). The significance and fold enrichment of DMR to each state was calculated as previously reported (Wahlberg et al., 2016).
Copyright and License information: ©2020 Huang, Hu, Zhang, Wang, Yang and Guo.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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