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The inclusion criteria for RCTs were double-blind design, clopidogrel and aspirin vs aspirin for the treatment of ischemic cardiovascular disease, age ≥ 18 years, subgroup analysis according to the presence of diabetes (if not reported, the corresponding author was contacted to obtain the data)[16], and a duration of treatment ≥ 3 mo[17]. We also included the CHARISMA trial, because the percentage of patients with documented vascular disease in the trial was high (78%)[14].
Copyright and License information: ©2020 The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
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