Ethics approval was granted by the Mexican National Council of Science and Technology, the Mexican Ministry of Health, and the University of Oxford. All study participants gave informed consent. Funding was received from the British Heart Foundation, the UK Medical Research Council, The Wellcome Trust (grant 058299/Z/99), and the Mexican Ministry of Health (Secretaria de Salud, Mexico). The funders had no input on the collection, analysis, or reporting of the data.
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