MRSA-Induced Sepsis Mouse Model

Seven-week old C57/BL6J male mice were randomly divided into seven groups in the survival test: MRSA (n=13), MRSA+XBJ (5 ml/kg) (n=13), MRSA+XBJ (10 ml/kg) (n=13), MRSA+DXM (7 mg/kg) (n=13), MRSA+DXM (7 mg/kg) +XBJ (5 ml/kg) (n=13), MRSA+VAN (110 mg/kg) (n=10), and MRSA+VAN (110 mg/kg)+XBJ (5 ml/kg) (n=10). All the mice were challenged by intraperitoneal injection of a lethal dose of MRSA [7 × 10⁸ colony-forming unit (CFU)/mouse] and treated simultaneously with XBJ, VAN, and DXM as indicated. Survival status was recorded in the following 7 days.