Statistical analysis

All statistical analyses were conducted using JMP 13 (SAS Institute Inc., Cary, NC, USA). The univariate analysis for continuous variables with normal distribution was compared using the Student's t-test. Continuous variables without a normal distribution were compared with Mann-Whitney's U test. A descriptive comparison was performed with the chi-squared test. Correlations between the presence of PHLF and continuous variables were expressed using Pearson's correlation coefficient. The area under the curve was calculated using the receiver operating characteristic (ROC) curve for the sensitivity and specificity of the value of the limit of telomere length. The difference between the two sides was considered statistically significant when the p-value was 0.05 or less. All relevant data are shown within Supporting Information files (S1 Table).