The genotype distributions of ADAM33 polymorphisms in the control group were tested for their conformity to Hardy-Weinberg equilibrium (HWE). Frequency differences in genotypes, alleles, and haplotypes were compared adopting chi-square test between the case and control groups. Odds ratio (OR) with 95% confidence interval (95%CI) was calculated to express the relative risk of childhood asthma. Data analyses were conducted utilizing PASW Statistics 18.0 software. P < .05 was considered as the significant threshold. Linkage disequilibrium (LD) and the role of haplotypes in childhood asthma were also analyzed.
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