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Allocation

AG Amanda Gwee
NC Noel Cranswick
SD Susan M Donath
RH Rodney Hunt
NC Nigel Curtis
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If the treating clinician determines that an infant requires treatment with vancomycin, the patient will be randomised in a 1:1 ratio to either CIV or IIV. The randomisation schedule will be generated by a statistician external to the study who will use random permuted blocking to ensure allocation concealment. At RCH, the infusion mode will be contained in sealed opaque envelopes, labelled consecutively with the randomisation numbers. At RHW, staff will randomise the infant using an online randomisation procedure. Clinicians will not be blinded to the allocated treatment.

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