Search

We searched MEDLINE, EMBASE, OviSP, and the ISI Web of Science from the date of database inception to 6 November 2017 using the following terms and keywords:

TXA, amino methyl carboxylic acid, amino methyl cyclohexane acid, cyklokapron, pharmacodynamics, pharmacokinetics, blood, plasma, human, fibrinolysis, fibrin, fibrinogen, antifibrinolytic, antifibrinolysis, clot, lysis, turbidity, immunoassay, immunochemistry, TEG, ROTEM, intravenous, oral, intramuscular, dose, dosing, concentration, and haemorrhage (see Appendix for detailed search strategy). Truncation symbols were used with the text words, when appropriate, to capture variations in spelling and word endings. We also examined the references of systematic reviews located during the search and performed a forward search with the eligible studies to identify further potential articles.