PRO Measure Assessment

Two investigators (M.N. and D.O.F.) independently assessed each study’s methods using a criteria checklist developed a priori (Table 1). In brief, the checklist was designed to help systematic reviewers identify components deemed important to the construction of PRO measures, including: (1) conceptual model, (2) content validity, (3) reliability, (4) construct validity, (5) scoring and interpretation, and (6) respondent burden and presentation. Definitions of these concepts are provided in the eTable in the Supplement. Each reviewer was trained and tested on appropriate application of the checklist using a method described separately. They were independently tasked with evaluating all identified PRO measures. On completion, reviewers (M.N. and D.O.F.) met to discuss and come to consensus on scoring discrepancies.