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2.11. Determination of Cardiotoxicity in Zebrafish

WK Wisurumuni Arachchilage Hasitha Maduranga Karunarathne
IM Ilandarage Menu Neelaka Molagoda
SP Sang Rul Park
JK Jeong Woon Kim
OL Oh-Kyu Lee
HK Hae Yun Kwon
MO Matan Oren
YC Yung Hyun Choi
HR Hyung Won Ryu
SO Sei-Ryang Oh
WJ Wol Soon Jo
KL Kyoung Tae Lee
GK Gi-Young Kim
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The cardiotoxicity of PS and PTS was determined by comparing the heart rate of zebrafish larvae at 6 dpf, because monitoring zebrafish heart rate is a great tool in drug development and toxicity study [26,27]. Briefly, zebrafish larvae were placed under a stereomicroscope (Olympus SZ2-ILST) for 4 min at room temperature for allowing embryos to acclimate to the light. The heart rate was calculated by counting the number of heart beats in 1 min. The obtained results were expressed as average heart rate per min.

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Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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