Statistical analyses were performed using R version 3.1.2 (R Foundation for Statistical Computing, http://www.R-project.org), compute.es package version 0.2‐4, hash package version 2.2.6, MASS package version 7.3‐45, mutoss package version 0.1‐10, pROC package version 1.8 and IBM SPSS Statistics version 22 (IBM Japan). The limit of statistical significance for all analyses was defined as a two‐sided P‐value of 0.05.
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