Animals

Twenty-four, male and female, purpose-bred dogs (one Beagle and 23 mongrels) ranging in age from 12 to 76 months, and weighing from 9.6 to 29.2 kg were used in the study. Each dog was individually identified by electronic transponder. All dogs had undergone an adequate wash-out period to ensure that no residual ectoparasiticide efficacy remained from any previously administered compound. The dogs were acclimatized to study conditions for a minimum of 14 days before the treatment on Day 0. Dogs were individually housed in indoor runs such that no physical contact was possible between them. Dogs were fed an appropriate maintenance ration of a commercial dry canine feed, and water was available ad libitum. All dogs were given a physical examination to evaluate general health and suitability for inclusion into the study. General health observations were performed at least once daily from the start of the acclimation period to the end of the study.