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Trial design

ŁD Łukasz Dobosz
TS Tomasz Stefaniak
MD Małgorzata Dobrzycka
JW Jagoda Wieczorek
PF Paula Franczak
DP Dominika Ptaszyńska
KZ Katarzyna Zasada
PK Peter Kanyion
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This trial is a prospective, open label, 1:1 randomized, controlled trial, conducted at a single institution. The aim of this study is to determine the effectiveness of invasive treatment of pain via splanchnicectomy, in patients with advanced pancreatic cancer. Assessments will not only include the usage of analgesic pharmacotherapy throughout the course of disease, and overall patient survival, but also subjective pain perception at rest, in movement, and after meals (measured by NRS score questionnaire), the patient’s quality of life (measured using the QLQ-C30 and FACIT questionnaires) [8, 9], and any pain-related suffering (measured with the PRISM projection test) [10, 11]. In addition, we intend to ascertain if earlier qualification for splanchnicectomy (upon lower steps of the WHO analgesic ladder) allows for a better therapeutic effect with this type of pain management.

A flow diagram of the trial is depicted in Fig. 1.

Flow diagram

Copyright and License information: Dobosz et al. ©2016
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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