MTX survival

MTX monotherapy was defined as the time during which a patient was receiving MTX as their sole DMARD for JIA. Time on MTX as monotherapy was calculated from the start date of MTX until the patient stopped MTX for the first time or started an additional DMARD or biologic therapy. Patients still on MTX monotherapy were censored at the last recorded study follow-up date, 31 December 2017 (cut-off date) or death, whichever came first. Patients who stopped therapy temporarily for whatever reason for <90 days were considered to be receiving continuous therapy. MTX drug survival was presented as a Kaplan–Meier curve over the first 2 years of therapy.