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A statistical analysis plan was prospectively defined. All the statistical analyses were performed using SAS version 9.4 (SAS Institute Inc., Cary, NC, USA).
Copyright and License information: Cancer Research UK ©2019
This work is published under the standard license to publish agreement. After 12 months the work will become freely available and the license terms will switch to a Creative Commons Attribution 4.0 International (CC BY 4.0).
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