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Validation of gene signature

JC Jessica G. Cockburn
RH Robin M. Hallett
AG Amy E. Gillgrass
KD Kay N. Dias
TW T. Whelan
ML M. N. Levine
JH John A. Hassell
AB Anita Bane
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To calculate a final prognostic index, gene Z scores were averaged by outcome association and then subtracted such that the average of poor outcome probesets was subtracted from the average of good outcome probesets, resulting in positive correlation to DMFS. Again, 10 year DMFS was used as the clinical endpoint and Cox PH Regression, C, and HRs were used to evaluate signature performance.

Copyright and License information: Cockburn et al. ©2016
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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