Statistical analysis

SPSS 22.0 (IBM, Chicago, IL, U.S.A.) was used for all statistical analyses, with significance defined as P<0.05. Subjects on accelerated or standard vaccination schedules were compared in terms of demographic characteristics, health-related behaviors, family history of hepatitis B, and anti-HBs seroconversion rate. Differences were assessed for significance using the Pearson χ² and Fisher’s exact tests. Multivariate binary logistic regression was used to compare anti-HBs seroconversion rates between the two vaccination schedules after controlling for age, gender, body mass index (BMI), smoking, drinking, anti-HBc, and family history of hepatitis B.

Anti-HBs concentrations were log-transformed to give them a normal distribution, and then used to calculate anti-HBs geometric mean concentration (GMC), which was compared between subjects on accelerated and standard vaccination schedules using the t test. GMC was also compared between subgroups of subjects stratified by different characteristics, and differences were assessed for significance using the t test, ANOVA, and Scheffe test. Finally, covariance analysis was used to compare anti-HBs GMC between the accelerated and standard schedules after controlling for various potential confounders.