4.17. Analysis of Microarray Datasets from GEO Database

A microarray dataset for adenocarcinoma gastric cancer, downloaded from GEO with accession number ({"type":"entrez-geo","attrs":{"text":"GSE13861","term_id":"13861"}}GSE13861) containing healthy (n = 19), intestinal-type (n = 20) and diffuse-type (n = 31) samples, was utilized to analyze the levels of FBXW5 mRNA expression across the three types of gastric tissues. A second independent microarray dataset of gastric cancer with accession number ({"type":"entrez-geo","attrs":{"text":"GSE103236","term_id":"103236"}}GSE103236) containing pairwise adjacent healthy (n = 9) and tumor tissues (n = 8) was employed to evaluate the levels of FBXW5 and ROCK1 mRNA expression across the three distinct tissues: Adjacent healthy, early tumor (n = 6), or advanced tumor (n = 3). In addition, GESA analysis was performed between high-FBXW5 and low-FBXW5 samples to explore the correlations between FBXW5 expression and genes involved in RhoA signaling, metastasis and advanced tumors.