Drugs Used for Fever Induction

We used 7 PAMP containing drugs (Table 1) in 19 different combinations (Table 2) to induce therapeutic fever in patients. Most of the patients were cancer patients. Others were treated for borreliosis (n=9), inflammation (n=9) and infection liability (n=4).

Selection of PAMP Drugs

Combinations of PAMP Drugs Tested for Safety and Fever Induction Capacity in Group B

Two drugs were bacterial extracts manufactured in close accordance with Coley's descriptions ("Se", sterile solution of Serratia marcescens, Streptococcus pyogenes; "Ps", sterile solution of Pseudomonas aeruginosa, Streptococcus pyogenes). Three drugs are approved for cancer therapy ("Co", Colibiogen; "Is", Iscador; "Pi", Picibanil). One drug is approved for i.v. application (Co), one other drug has been tested for i.v. application extensively (Is) [25]. So part of the drugs were used off-label with respect to disease approval and/or way of transmission (i.v.). All patients were informed accordingly and signed informed consent. For all drugs used, fever is described as frequent side reaction in the respective instruction leaflets. All drugs contain, as jugded by ingredients, PAMP. All drugs are approved in at least one EU state and can therefore be applied EU wide.