Calculation of parameters that define the shape of VAF distribution shape

We only used samples with ≥ 2 MF mutations to calculate the three parameters that define the shape of VAF distributions: the corresponding VAF with the maximum value for probability density function of VAF distribution of MF mutations (m_Peak), log2[the total number of MF mutations] (m_Count) and MATH score for MF (m_MATH) [13]. The m_Peak indicates the peak position of the VAF distribution, the m_Count indicates the size for distribution, and the m_MATH indicates the variation of VAFs. We used these three parameters because they define overall shape of VAF distribution for MF.