AmiGO GO Slimmer

AmiGO is a web application that allows users to query, browse and visualize ontologies and related gene product annotation (association) data. AmiGO can be used online at the Gene Ontology (GO) website to access the data provided by the GO Consortium; it can also be downloaded and installed to browse local ontologies and annotations. AmiGO is free open source software developed and maintained by the GO Consortium. Its functionality contained blast, term enrichment and GO Slimmer, etc. The function of the GO Slimmer tool is to remap granular, specific annotations up to a user-specified set of high-level terms. This subset of terms, referred to as a GO slim, provides a useful overview of a dataset and facilitates the reporting and analysis of large result sets, such as GO annotations to a genome or microarray expression data [57]. In this study, AmiGO GO Slimmer was utilized to map genes into GO slim terms according to their biological process. SGD was used as a database filter (Evidence Code: all), and Yeast GO slim was used as a preexisting GO slim set. The advanced results option was used to display gene products and counts for each slim term.