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Tissufleece/tissucol Duo® (collagen-based sealant/fibrin glue)

HF Hamidreza Fonouni
EK Elias Khajeh
OG Omid Ghamarnejad
AK Arash Kashfi
EA Emre Aydogdu
AM Ali Majlesara
SM Sara Mohammadi
NG Negin Gharabaghi
LK Lukas Konstantinidis
TL Thomas Longerich
AM Arianeb Mehrabi
YK Yakup Kulu
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Tissufleece® (Baxter; Unterschleißheim, Germany) is a natural equine collagen and is an appropriate hematostatic material for covering the bleeding surface. It consists of heterologous collagen fibrils acquired from devitalized connective tissue and is fully reabsorbable. Tissucol Duo® is a typical two component adhesive. The first part includes human plasma proteins (fibrinogen, factor XIII, plasma fibronectin, and the plasmin inhibitor aprotinin). The second part includes thrombin and CaCl2. Prior to application of Tissucol Duo®, injectors were kept for 20–30 min at room temperature for melting. The “treatment surface” was covered with a combination of the two injector contents and the TissuFleece® boards were attached and left for 2 min. Two TissuFleece® plates and 4 ml Tissucol Duo® were applied to seal the hepatic resection field.

Copyright and License information: The Author(s) ©2019
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