FCs analysis between the 12 insular subdivisions and the whole brain

The ROI-whole brain analysis was conducted between the 12 insular subdivisions (a total of 12 ROIs) and the whole brain. The mean time series for each ROI were calculated and then correlated with the time courses of all other voxels in the brain for each subject. Pearson correlation coefficients were converted to normally distributed scores by use of the Fisher’s r-to-z transformation [23]. Group-level analysis for the general linear model was performed applying two sample t-test between the z-scores of the male and female groups. The reported results of the ROI-whole brain correlation analysis were carried out performing an uncorrected peak level of p < 0.001 to correct for false positive rates and a false discovery rate (FDR) correction by using SPM8 at cluster level for multiple comparisons with threshold of p < 0.05 [29, 30].