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4-[4-(Biphenyl-4-sulfonyl)-piperazin-1-yl]-7-trifluoromethyl-quinoline (18)

VS V. Raja Solomon
SP Sheetal Pundir
HL Hoyun Lee
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White solid; 76% yield; mp 148–150 °C; IR (KBr, cm−1) 1165.3 (SO2); 1H NMR (500 MHz, CDCl3): δ 3.37 (s, 4 H, N(CH2CH2)2N-Ar), 3.43 (s, 4 H, N(CH2CH2)2N-Ar), 6.97–6.98 (d, J = 5.0 Hz, 1 H, Ar-H), 7.45–7.47 (d, J = 10.0 Hz, 1 H, Ar-H), 7.48–7.52 (m, 2 H, Ar-H), 7.53–7.55 (d, J = 10.0 Hz, 2 H, Ar-H), 7.61–7.63 (d, J = 10.0 Hz, 2 H, Ar-H), 7.66–7.68 (d, J = 10.0 Hz, 2 H, Ar-H), 7.98–8.00 (d, J = 10.0 Hz, 2 H, Ar-H), 8.37 (s, 1 H, Ar-H), 8.85–8.86 (d, J = 5.0 Hz, 1 H, Ar-H); 13C NMR (125 MHz, CDCl3): δ 45.99, 46.05, 51.52, 51.59, 110.78, 121.27, 124.53, 124.96, 127.35, 127.91, 128.05 (2 C), 128.38 (2 C), 128.72 (2 C), 129.17 (2 C), 129.30, 130.97, 134.06, 139.08, 146.18, 148.73, 152.24, 155.91; ES-MS m/z 499 [M + H]+; Anal.Calcd for C26H22F3N3O2S: C, 62.77; H, 4.46; N, 8.45; found: C, 62.77; H, 4.46; N, 8.45.

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