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Computing the probability of detecting at least one T > C read for a 3’ interval
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Based on the notation developed above, we can compute the expected number of reads showing a T > C conversion given pSU and pT→C for a 3' interval with n sequenced reads as
When taking into account empirically determined sensitivity of SLAMDUNK S, i.e. the probability of detecting a read with T > C conversion as a labeled read, we compute the probability of detecting at least one labeled read for a 3′ interval given pSU and pT → C as:
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