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The sedative effects of MP1104 were measured using spontaneous locomotor activity tests. Before testing, rats were habituated in the activity chambers for 30 min, then injected with either vehicle or MP1104 (0.3, 0.6 or 1 mg/kg, i.p.) and placed in the activity chamber for 60 min (n = 8 per group). Horizontal locomotor activity was measured for 60 min. Infrared beam-breaks were recorded as ambulatory counts (Med Associates: ENV-520; SOF-811). Testing was performed in dark between 9:00 and 17:00 h in the presence of white noise (67 dB).
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