2.5. GO function enrichment analysis

In the constructed network, for each miRNA, we performed the Gene Ontology (GO) function enrichment analysis for their target genes. We used clusterProfiler package of R software (http://www.r-project.org) to implement this analysis. The multiple testing corrections based on Benjamini-Hochberg method [18] were performed; those GO terms whose adjusted p-values were less than 0.05 were considered significant.