All the data are presented as means ± standard errors of the means (SEM). Differences between two groups were assessed using an analysis of variance, followed by Student's t-test. A P value <0.05 was considered statistically significant. The statistical analysis was performed using Prism 5 software (GraphPad Software, San Diego, CA, USA). For xenograft experiments, sample sizes were calculated using the standard deviations from preliminary experiments and the expected difference between two groups. Other sample sizes were equal to or greater than the recommended minimum sample sizes in previous publications.
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