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2.1.4. Preparation of analogs of cpd 3 varying by the amide substitution (compounds 12–28)

AM André Malanda
PA Pierre-Yves Abécassis
PB Pascal Barnéoud
PB Pascale Brunel
VT Véronique Taupin
XV Xavier Vigé
DL Dominique Lesuisse
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The compounds 12 to 28 are obtained by coupling the 6-(pyridin-2-yl)imidazo[1,2-a]pyridine-2-carboxylic acid with the appropriate aromatic amines according to the procedures described in Refs. [4], [6].

N-3,5-difluorophenyl-6-(pyrid-2-yl)imidazo[1,2-a]pyridine-2-carboxamide (cpd 12) [5].

N-2-chlorophenyl-6-(pyrid-2-yl)imidazo[1,2-a]pyridine-2-carboxamide (cpd 13) [5].

N-3-fluorophenyl-6-(pyrid-2-yl)imidazo[1,2-a]pyridine-2-carboxamide (cpd 14) [5].

N-2-fluorophenyl-6-(pyrid-2-yl)imidazo[1,2-a]pyridine-2-carboxamide (cpd 15) [5].

N-2,5-difluorophenyl-6-(pyrid-2-yl)imidazo[1,2-a]pyridine-2-carboxamide (cpd 16) [5].

N-2,3-difluorophenyl-6-(pyrid-2-yl)imidazo[1,2-a]pyridine-2-carboxamide (5, cpd 17) [5].

N-2-cyanophenyl-6-(pyrid-2-yl)imidazo[1,2-a]pyridine-2-carboxamide (cpd 18) [5].

N-6-di(pyridin-2-yl)imidazo[1,2-a]pyridine-2-carboxamide (cpd 19) [7].

N-6-fluoropyridin-2-yl-6-(pyrid-2-yl)imidazo[1,2-a]pyridine-2-carboxamide (cpd 20) [7].

N-Thien-3-yl -6-(pyrid-2-yl)imidazo[1,2-a]pyridine-2-carboxamide (cpd 21) [7].

N-Thiazol-2-yl -6-(pyrid-2-yl)imidazo[1,2-a]pyridine-2-carboxamide (cpd 22) [7].

N-Isoxazol-3-yl -6-(pyrid-2-yl)imidazo[1,2-a]pyridine-2-carboxamide (cpd 23) [7].

N-1,3,4-Thiazol-2-yl -6-(pyrid-2-yl)imidazo[1,2-a]pyridine-2-carboxamide (cpd 24) [7].

N-Pyrazol-3-yl -6-(pyrid-2-yl)imidazo[1,2-a]pyridine-2-carboxamide (cpd 25) [7].

N-Tetrahydropyridinyl -6-(pyrid-2-yl)imidazo[1,2-a]pyridine-2-carboxamide (cpd 27) [8].

N-Indolyl -6-(pyrid-2-yl)imidazo[1,2-a]pyridine-2-carboxamide (cpd 28) [8].

Copyright and License information:  ©2019 The Authors
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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