2.9. The relationship between changes in functional connectivity over time and anatomical lesion location

Euclidean distances from each voxel to the infarct area in MNI152 (3 mm³) space using three-dimensional voxel coordinates were computed for each patient. The resulting anatomical distance values were correlated with concordance values (using Pearson's correlation coefficient). A regression analysis was applied to remove the contribution of this factor from concordance values. Residuals were correlated with gradient-based distance-to-lesion values (using Spearman's rank-order correlation coefficient).