To enrol the required number of patients in the planned recruitment period, 12 trial sites of the Clinical Trials Network of the German Surgical Society (CHIR-Net) will participate in this trial (www.chir-net.de). These 12 centres will be high-volume centres committing to include at least 50 patients each. To improve recruitment at all centres, brochures and flyers for patients including information about the trial will be available.
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