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Visualization of folded domains and mutation spectra
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Figures were prepared using the program PyMOL58. The KRAS structure used is the GDP-bound full-length KRAS4b (PDB code: 5TAR)59. The NRAS structure used is the GppNHp-bound NRAS structure, which is 166 residues (PDB code: 5UHV)32. The HVR is not represented in this resolved structure. Another available NRAS structure (PDB code: 3CON) was not used as it lacks information on residues 61–71. The HRAS structure32,60 (PDB code: 1CTQ) used is the GppNHp-bound HRAS structure, which is 166 residues; this structure does not resolve the HVR.
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