Although we have internal quality control methods to ensure data integrity, follow-up nonresponse shall be an inescapable challenge in a prospective observation study. Fortunately, we will recruit experienced physicians with stable patient population (at least 5 years of acupuncture experience or middle and senior titles), so the bias for lack of follow-up could be controlled partially. Real-time monitoring of the electronic network platform shall control missing data less than 20%. According to the classical rules of missing classification, follow-up nonresponse belongs to missing not at random (MNAR) [40]. Multiple imputation invented by Rubin shall be adopted to process missing data [41].
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