To evaluate how MPs would be involved in certain kinds of pathways during tumorigenesis, we first collected 292 human pathways containing 8962 proteins from the KEGG database and then derived 22 cancer pathways belonging to the categories “Cancers: Overview” (e.g., viral carcinogenesis) and “Cancers: Specific types” (e.g., colorectal cancer-related pathway) in human diseases. Next, some pathways that were linked to these cancer pathways were regarded as related pathways. For example, there were 30 related pathways, such as the cell cycle, apoptosis, and adherens junction, recorded in the pathways in cancer (hsa05200). Finally, these 22 cancer pathways and 43 non-redundant related pathways were deemed cancer-related pathways (total of 65; Supplementary Table 1).
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