Robustness across subjects

The percent of BRO-significant was tested for robustness using the ABA6-2013 dataset, where hundreds of samples are available for each subject. For each gene, we calculated its BRO-score but this time for each subject separately. The fraction of genes with a significant BRO score (p-value < 0.01) is stable across the individual subjects, yielding 89%, 90%, 76%, 91%, 83% and 86% (supplementary S7 Fig). The fraction of significant genes at the group level is slightly higher; suggesting that the groups score manages to remove some of the inter-subject noise.