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Go/No-Go inhibition fMRI task

RW Robert H. Wichers
JF James L. Findon
AJ Auke Jelsma
VG Vincent Giampietro
VS Vladimira Stoencheva
DR Dene M. Robertson
CM Clodagh M. Murphy
GM Grainne McAlonan
CE Christine Ecker
KR Katya Rubia
DM Declan G. M. Murphy
ED Eileen M. Daly
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In order to probe the brain’s response inhibition system, a Go/No-Go task was performed during each scanning session19,46. During this task, either a motor response on a button box to Go signals is required or the inhibition of this response to No-Go signals. Arrows pointing to either the left or right side appear on the screen. The subject has to press the left or right response button on a diamond-shaped keypad as response. Infrequently (12%), arrows pointing to the top (No-Go signals) appear. Subjects have to inhibit their motor response to these stimuli. In 12% of trials, slightly slanted arrows pointing left or right appear and subjects have to treat them the same way as Go signals. In order to control for the attentional oddball effect due to the low frequency occurrence of No-Go trials, No-Go trials were compared to successful oddball trials19,46.

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