Liver laceration hemostasis model

All procedures involving animals were approved by the University of British Columbia or McMaster University Animal Care Committee and performed in accordance with the guidelines established by the Canadian Council on Animal Care. As previously described [34], 6-week-old female CD-1 mice (Charles River, Montreal, Canada) were anesthetized by inhalation of vaporized isofluorane and the liver was accessed through a 3-cm transverse incision. Xai-K or TNK were injected via the tail vein. A 2 mm × 2 mm incision was made in the liver and blood loss after 10 min was quantified by weight absorbed onto filter paper.