Statistical analysis was performed using SPSS version 23.0 (IBM Corp., Armonk, NY, USA). Results were presented as mean ± standard deviation for continuous variables. Differences pre- and post- PAH-targeted therapies were compared using paired t-test and drawn by GraphPad Prism Version 5.0 (GraphPad Software Inc., San Diego, CA, USA). A two-sided P < 0.05 was considered statistically significant.
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