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Global sensitivity analysis

AM Arash Moshkforoush
BA Baarbod Ashenagar
NT Nikolaos M. Tsoukias
BA B. Rita Alevriadou
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Robustness of the model was assessed using a global sensitivity analysis of model parameters. Each parameter of the model was allowed to vary within a lower and upper bound (±40% of the control values; Supplementary Table S1), and the Latin hypercube sampling (LHS) method52,53 with uniform distribution was used to select 250,000 random parameter sets. The model was solved for each set and the partial rank correlation coefficient (PRCC) analysis was performed to identify parameters that exerted statistically significant positive or negative influences on [Ca2+]Cyt oscillations. For all the analyses, 95% confidence interval was chosen for statistical significance.

A graphical user interface (GUI)-enabled MATLAB implementation of the model is available online (see https://tsoukias.fiu.edu/models/mitocaldynamics).

Copyright and License information: The Author(s) ©2019
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