Data analyses were performed using SPSS Statistics software (version 21, IBM Inc., Armonk, NY, USA). Dose effects of andrographolide were compared to untreated controls using analysis of variance (ANOVA) with Dunnett’s post hoc tests, while other pair-wise comparisons of the experimental groups were performed using ANOVA followed by Bonferroni’s post hoc tests, with p values <0.05 considered statistically significant. All experiments were performed independently at least three times.
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