Categorical variables were described as percentages and analyzed through Chi-Squared test with Yates’ correction or Fisher exact test if expected values were <5.
We estimated the number of CP and PP hospitalizations per 10,000 hospital discharges for children ≤ 15 years of age, hospitalized for any cause, per year. Changes in CP and PP rates between the pre-vaccination period 2007–2011 (preVp), the year when PCV13 was introduced (intervention year, 2012) and the post-vaccination period 2013–2014 (postVp) were assessed using the Preventive Fraction in exposed (PFe) formula PFe% = [(Rate preVp–Rate postVp)/ Rate preVp] x 100, with 95% confidence intervals (CIs).
Statistical analysis was performed using Epi Info TM 7 (CDC, Atlanta) and the Open Epi (Open Source Epidemiologic Statistics for Public Health, Version. www.OpenEpi.com, updated on: 2013/04/06). Two-tailed P values <0.05 were considered statistically significant.
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