2.9. Effect of PGR-BD score on group differences on task-related activation

The effect of group (patients, relatives controls) was examined separately for each paradigm (affect faces > neutral faces; 2-back > baseline) using a general lineal model in SMP8 with the BPRS total score as covariate. In each of these analyses, supra-threshold clusters signifying group differences were identified using FWE correction of p < 0.05, k > 20. Beta values were extracted from each supra-threshold cluster using the eigenvariate function in SPM8. To test whether the PGR-BD score explained additional variance in group differences, Pearson's correlation analyses were used to examine the relationship between mean signal change in the suprathreshold clusters and PGR-BD score in SPSS22, with relatedness as a covariate.