Search strategy

No prior published studies that addressed similar topics were found in PubMed, MEDLINE (via Ovid), and EMBASE (via Ovid). Similar systematic review study protocols have not been registered on PROSPERO. A health sciences librarian (LS) searched the following databases: MEDLINE and MEDLINE in Process (via OVID), Embase Classic + Embase (via OVID), Cochrane’s Central Registry for Randomized Controlled Trials, CENTRAL (via OVID), and PubMed. Appendix 1 demonstrates our search strategy, which was initially developed in MEDLINE then translated into other databases. All databases will be searched from the date of inception to April 1, 2019. No language exclusion criteria nor other publication restrictions were incorporated into the search strategy. All references will then be entered into EndNote (version X9, Clarivate Analytics Inc., Philadelphia, PA) citation manager for processing. Supplemental search will consist of manual scanning of bibliographies in eligible studies, grey literature search of clinical trial registries such as clinicaltrials.gov, and screening for relevant titles in the first three pages of the Google Scholar search. Relevant articles will be screened at two levels: title/abstract then full-text screening, by two reviewers (CW and EC) in the systematic review software, Covidence (Veritas Health Innovation LTD).