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We searched for studies evaluating 18F-FDG PET/CT for the detection of distant metastasis in NSCLC patients at initial staging. Articles were identified with a search of the MEDLINE and Embase databases through October 29, 2017. We used a search algorithm that was based on a combination of text words: PET/CT, positron emission tomography/computed tomography, PET-CT, positron emission tomography-computed tomography, non-small cell lung cancer, NSCLC, staging, and distant metastasis. We had no language restrictions for searching and selecting relevant studies. References of pertinent articles (the retrieved articles, meta-analysis, reviews, and editorials) and guidelines were also screened manually to retrieve additional eligible studies. Authors of eligible studies were contacted and asked to supplement additional data when key information was missing.

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