Modification of statin or radiation therapy dosing

Lovastatin was discontinued if transaminases became elevated ≥3 times above the upper limit of normal or if CK levels became elevated. For other side effects thought to be due to lovastatin, if ≤ Grade 2, the dose was lowered to 10 mg/day, and if ≥ Grade 3, the drug was stopped and the patient was removed from the study. Radiation treatment interruptions were permitted, but were to be kept to a minimum, and criteria for a treatment break were up to the attending physician. Once radiation commenced, changes in fractionation were not permitted. Patients were to remain on lovastatin during any treatment breaks.