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Study endpoints

SJ Sophie Jacob
AP Atul Pathak
DF Denis Franck
IL Igor Latorzeff
GJ Gaelle Jimenez
OF Olivier Fondard
ML Matthieu Lapeyre
DC Daniel Colombier
EB Eric Bruguiere
OL Olivier Lairez
BF Benoit Fontenel
FM Fabien Milliat
RT Radia Tamarat
DB David Broggio
SD Sylvie Derreumaux
MD Marianne Ducassou
JF Jean Ferrières
DL Dominique Laurier
MB Marc Benderitter
MB Marie-Odile Bernier
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The primary endpoint is a subclinical cardiac outcome defined as follows: between baseline (before RT) and 2 years post RT, a decrease in the global and segmental longitudinal strain or strain rate measured by 2D-STE of at least 5 % and/or an increase in the number of coronary segments containing any plaque measured by CCTA of at least 15 %. These average percentages were chosen based on those observed in previous studies and can be considered clinically pertinent [17, 34–37].

The secondary endpoints are:

Decrease in the strain or strain rate between measurements made before RT and 6 months after RT.

Modified series of biomarkers between the measurements before RT and: just after RT, 6 months after RT, 24 months after RT.

Correlation between the absorbed radiation dose to the whole heart and different structures of the heart and measurements of strain and strain rate and number of coronary segments containing any plaque measured 2 years after RT.

Copyright and License information: Jacob et al. ©2016
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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